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Dieses Dokument ist nur für den persönlichen Gebrauch bestimmt und darf in keiner Form an Dritte weitergegeben werden. It appears premature to expect translation of existing genetic findings to novel treatments in the near future (Martin and Raphael, 2003), as the identification of valid biomarkers that may guide research remains a difficult task (Savastano et al. For example, CDKN2A mutations (which may be detected in melanoma-prone families) confer a four-fold increased risk for the development of breast cancer and a 30-fold increased risk of pancreatic cancer.

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